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Kimani, Martin K.; Mwangi, John; Goluch, Edgar D. (, Journal of Analysis and Testing)
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Kimani, Martin; Loo, Rachel; Goluch, Edgar D (, Micro total analysis systems)This paper presents an integrated microfluidic system that uses dialysis membranes coupled with electrochemical sensing to concentrate bodily fluid samples up to a hundred fold while simultaneously monitoring the process in-line. Sensors measure both the conductivity and the sucrose concentration in the sample while it is being concentrated using impedance spectroscopy and voltammetry, respectively. This sample concentration technique can be coupled with many microanalysis systems to process samples and improve the limit of detection. We have concentrated samples up to 100x by using two forward osmosis concentrators in series.more » « less
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